Biological Foundations

Using our breakthrough model of evolution, we’re aiming to establish new foundations for theoretical biology.

Project Overview

We recently developed a cellular-automata based model of evolution where complex phenotypes emerge “bottom-up”. This new characterization of phenotype-space is beginning to produce long-awaited explanations for many bulk phenomena observed in biology, and from these explanations, important consequences are emerging for fields like virology, immunology and ecology.

Research Output

Community Output

  • What If We Had Bigger Brains? Imagining Minds beyond Ours

    Stephen Wolfram - May 21, 2025

    We humans have perhaps 100 billion neurons in our brains. But what if we had many more? Or what if the AIs we built effectively had many more? What kinds of things might then become possible?

  • What Can We Learn about Engineering and Innovation from Half a Century of the Game of Life Cellular Automaton?

    Stephen Wolfram - March 18, 2025

    Things are invented. Things are discovered. And somehow there’s an arc of progress that’s formed. But are there what amount to “laws of innovation” that govern that arc of progress?

  • Towards a Computational Formalization for Foundations of Medicine

    Stephen Wolfram - February 3rd, 2025

    New insight from our model into the field of medicine.

  • Foundations for Biological Evolution: More Results & More Surprises

    Stephen Wolfram - December 5th, 2024

    Powerful new results from the cellular-automata model of evolution.

  • Why Does Biological Evolution Work? A Minimal Model for Biological Evolution and Other Adaptive Processes

    Stephen Wolfram - May 3rd, 2024

    The initial outline and exploration of the model.

  • Can AI Solve Science?

    Stephen Wolfram - March 5, 2024

    Won’t AI Eventually Be Able to Do Everything?

  • Computational Foundations for the Second Law of Thermodynamics

    Stephen Wolfram - February 3, 2023

    The Second Law: Resolving the Mystery of the Second Law of Thermodynamics

Live Science Recordings

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